A combined nearly 4,000 acres were listed for sale in Chester County recently; the value of all Chester County land and rural real estate for sale was $67 million. Chester County ranks 32nd in South Carolina for the total number of acres of land currently advertised for sale. Chester had the most land for sale. Manufacturing and related services are the largest economic sectors in Chester County. Chester County is South Carolina's 26th biggest county (586 square miles). It's located in the Midlands South Carolina region of the state.