Of 46 counties in the Palmetto State, Colleton County is fourth in terms of its size (1,133 square miles). Colleton County is in Low Country South Carolina. A recent survey of Land Network data totals almost 1,000 acres of ranches for sale in South Carolina's Colleton County, which is valued at a combined $162,000. Browse all Colleton County ranches for sale on the Land Network to find the ranch that's right for your business or commercial needs, from the sprawling legacy ranch to unbelievable residential ranch for your second home, investment property or retirement nest egg. The most common type of land for sale by combined acreage in Colleton County is residential property.