Land for sale in Columbia County, Florida, recently totaled approximately $203 million and 4,000 acres. Columbia County ranks 31st in the Orange State for the total number of acres of land currently advertised for sale. There were five properties listed as sold in Columbia County through the Land Network Comparable Sales Program. This represented a total value of $470,090. Of all farms and rural real estate for sale in Columbia County, Lake City had the most land for sale. Government and state-level services are the main economic drivers in Columbia County. Columbia County is the 37th largest county (801 square miles) in Florida. It's located in the North Central Florida region of the state.