Land for sale in Florida's DeSoto County recently totaled $137 million and approximately 8,000 acres. DeSoto County ranks 62nd in the Sunshine State for the combined amount of land currently advertised for sale. Among cities in DeSoto County with farms and rural real estate for sale, Arcadia had the most land for sale. DeSoto County is the 49th biggest county (639 square miles) in Florida. It's located in the Central West Florida region of the state.