The value of land and rural real estate for sale in Dona Ana County, New Mexico, recently on Land.com was around $246 million. This represents nearly 6,000 acres of land for sale in Dona Ana County. Dona Ana County ranks sixth out of 33 counties in the Land of Enchantment for the total acreage of land currently advertised for sale. Of all locations in Dona Ana County with farms and ranches for sale, Las Cruces featured the most land for sale. Dona Ana County is New Mexico's 16th largest county (3,814 square miles). It's located in the Southwest New Mexico region of the state.