Land for sale in New Mexico's Guadalupe County recently totaled nearly $55 million and around 100,000 acres. Guadalupe County ranks 29th in the Land of Enchantment for the total acreage of land currently advertised for sale. Of all ranches, farms, hunting land and other rural land and acreage for sale in Guadalupe County, Santa Rosa had the most land for sale. Based on its natural assets, tourism and recreation are important factors in the Guadalupe County economy. Guadalupe County is the 21st biggest county (3,030 square miles) in New Mexico. It's located in the Northeast New Mexico region of the state.