There was a total of $31 million of land and rural real estate for sale in Guadalupe County recently on Land.com. The total acreage of all Guadalupe County farms and ranches for sale was 100,000 acres. Guadalupe County ranks 30th in the state for the combined amount of land currently advertised for sale. Santa Rosa featured the most land for sale. Based on its natural assets, tourism and recreation are important sectors for the Guadalupe County economy. Guadalupe County is the 21st biggest county (3,030 square miles) in New Mexico. It's located in the Northeast New Mexico region of the state.