South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. Land for sale in Guadalupe County, Texas, recently totaled around $571 million and approximately 100,000 acres. Guadalupe County ranks 38th in Texas for the total number of acres of land currently advertised for sale. There were four properties listed as sold in Guadalupe County through the Land Network Comparable Sales Program. This represented a total value of $3,460,000. Of all land for sale in Guadalupe County, Seguin had the most land for sale. Guadalupe County is the 215th biggest county (714 square miles) in Texas. It's located in the San Antonio Texas region of the state.