South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. A total of approximately 100,000 acres were listed for sale in Texas's Guadalupe County recently, representing a combined almost $481 million in Guadalupe County land and rural real estate for sale. Guadalupe County ranks 36th in the Lone Star State for the total number of acres of land currently advertised for sale. Seguin had the most land for sale. Guadalupe County is the 215th biggest county (714 square miles) in Texas. It's located in the San Antonio Texas region of Texas.