South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. The total value of land for sale in Guadalupe County, Texas, recently on Land.com was approximately $499 million. This represents around 100,000 acres of land for sale in Guadalupe County. Guadalupe County ranks 37th in the Lone Star State for the total acreage of land currently advertised for sale. Of all locations in Guadalupe County with land for sale, Seguin featured the most land for sale. Guadalupe County is the 215th biggest county (714 square miles) in Texas. It's located in the San Antonio Texas region of the state.