South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. There was a combined almost $483 million of farms, ranches, and rural real estate for sale in Guadalupe County, Texas, recently on Land.com. The total acreage of all Guadalupe County land for sale was around 100,000 acres. Guadalupe County ranks 36th in the Lone Star State for the combined amount of land currently advertised for sale. Among cities in Guadalupe County with farms, ranches, hunting land and other land for sale, Seguin had the most land for sale. Guadalupe County is the 215th biggest county (714 square miles) in Texas. It's located in the San Antonio Texas region of the state.