The Texas Panhandle gets its name for its proximity to the handle-shaped portion of its neighbor, Oklahoma. It is the state's least populated region. Land for sale in Hemphill County recently totaled nearly $4 million and 2,000 acres. Hemphill County ranks 249th out of 254 counties in the Lone Star State for the total number of acres of land currently advertised for sale. Among cities in Hemphill County with land and rural real estate for sale, Canadian had the most land for sale. Economically speaking, Hemphill County's is largely dependent on mining and mineral extraction-related businesses and services. Hemphill County is the 142nd biggest county (912 square miles) in Texas. It's located in the Panhandle Texas region of Texas.