The value of land for sale in Holmes County, Ohio, recently on Land.com was around $9 million. This represents almost 1,000 acres of ranches, farms, hunting land and other rural land and acreage for sale in Holmes County. Holmes County ranks 74th out of 88 counties in the Buckeye State for the total acreage of land currently advertised for sale. Millersburg had the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Holmes County. Holmes County is Ohio's 55th largest county (423 square miles). It's located in the Southeast Ohio region of Ohio.