A total of almost 1,000 acres were listed for sale in Holmes County recently, representing a total value of $14 million in Holmes County farms and ranches for sale. Holmes County ranks 70th out of 88 counties in the Buckeye State for the total number of acres of land currently advertised for sale. Of all locations in Holmes County with farms, ranches, and rural real estate for sale, Millersburg featured the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Holmes County. Holmes County is the 55th biggest county (423 square miles) in Ohio. It's located in the Southeast Ohio region of Ohio.