There was a combined almost $19 million of land for sale in Holmes County recently on Land.com. The total of all Holmes County farms, ranches, and rural real estate for sale was 1,000 acres. Holmes County ranks 60th out of 88 counties in the state for the combined amount of land currently advertised for sale. Of all ranches, farms, hunting land and other rural land and acreage for sale in Holmes County, Millersburg had the most land for sale. Manufacturing and related services are the largest economic sectors in Holmes County. Holmes County is Ohio's 55th largest county (423 square miles). It's located in the Southeast Ohio region of Ohio.