The total value of land for sale in Knox County, Missouri, recently on Land.com was nearly $5 million. This represents almost 1,000 acres of farms, ranches, and rural real estate for sale in Knox County. Knox County ranks 112th out of 115 counties in the Show Me State for the total acreage of land currently advertised for sale. Novelty had the most land for sale. Agriculture and farming drives the Knox County economy, with 695 farms recorded in the county during the U.S. Census in 2012. Farming activities in Knox County generate annual revenues of $21 million, the majority of which comes from livestock products. Knox County is Missouri's 83rd biggest county (506 square miles). It's located in the Northeast Missouri region of Missouri.