There was a combined nearly $834 million of land for sale in Lake County, Florida, recently on Land.com. The total acreage of all Lake County land and rural real estate for sale was almost 100,000 acres. Lake County ranks 11th in Florida for the combined amount of land currently advertised for sale. Clermont had the most land for sale. Lake County is the 18th biggest county (1,156 square miles) in Florida. It's located in the Central Florida region of Florida.