A total of approximately 1,000 acres were listed for sale in Letcher County, Kentucky, recently, representing a total value of almost $4 million in Letcher County farms and ranches for sale. Letcher County ranks 114th in the Bluegrass State for the total number of acres of land currently advertised for sale. Isom featured the most land for sale. Letcher County is the 55th largest county (339 square miles) in Kentucky. It's located in the Eastern Kentucky region of the state.