Land for sale in Manitowoc County recently totaled $30 million and nearly 1,000 acres. Manitowoc County ranks 58th out of 72 counties in Wisconsin for the combined amount of land currently advertised for sale. Of all locations in Manitowoc County with land for sale, Manitowoc featured the most land for sale. Manufacturing and related services are the largest economic sectors in Manitowoc County. Manitowoc County is one of the ten biggest counties in Wisconsin (1,494 square miles). It's located in the Northeast Wisconsin region of the state.