Land for sale in McDonald County recently totaled approximately $88 million and almost 6,000 acres. McDonald County ranks 24th out of 115 counties in the state for the combined amount of land currently advertised for sale. Of all locations in McDonald County with land and rural real estate for sale, Noel featured the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in McDonald County. McDonald County is Missouri's 72nd biggest county (539 square miles). It's located in the Southwest Missouri region of the state.