The total value of land for sale in McDuffie County, Georgia, recently on Land.com was nearly $15 million. This represents 1,000 acres of farms, rural land, hunting land and other land for sale in McDuffie County. McDuffie County ranks 149th out of 159 counties in the state for the total number of acres of land currently advertised for sale. Thomson had the most land for sale. Manufacturing and related services are the largest economic sectors in McDuffie County. McDuffie County is the 117th biggest county (266 square miles) in Georgia. It's located in the Historic South Georgia region of the state.