Land for sale in McDuffie County recently totaled $15 million and almost 1,000 acres. McDuffie County ranks 151st in the state for the total acreage of land currently advertised for sale. Of all locations in McDuffie County with land and rural real estate for sale, Thomson featured the most land for sale. Manufacturing and related services are the largest economic sectors in McDuffie County. McDuffie County is Georgia's 117th largest county (266 square miles). It's located in the Historic South Georgia region of Georgia.