A total of approximately 100,000 acres were listed for sale in Colorado's Mesa County recently; the combined value of all Mesa County land and rural real estate for sale was around $556 million. Mesa County ranks fifth in the Mile High State for the combined amount of land currently advertised for sale. Of all farms, ranches, and rural real estate for sale in Mesa County, Grand Junction featured the most land for sale. Mesa County is one of the ten largest counties in Colorado (3,341 square miles). It's located in the Northwest Colorado region of the state.