The value of all land and rural real estate for sale in Monroe County recently was $1 billion, representing a total of 12,931 acres of land for sale in Monroe County. Monroe County ranks 53rd in the Everglade State for the total acreage of land currently advertised for sale. Of all locations in Monroe County with farms and rural real estate for sale, Key Largo featured the most land for sale. Based on its natural assets, Monroe County's economy is dependent on tourism and recreation. Monroe County is the largest county in Florida (3,737 square miles). It's located in the Southeast & The Keys Florida region of Florida.