The value of ranches, farms, hunting land and other rural land and acreage for sale in New Madrid County recently on Land.com was approximately $20 million. This represents nearly 3,000 acres of farms and ranches for sale in New Madrid County. New Madrid County ranks 97th out of 115 counties in the Gateway State for the total number of acres of land currently advertised for sale. Of all locations in New Madrid County with land and rural real estate for sale, Portageville featured the most land for sale. New Madrid County is the 33rd biggest county (696 square miles) in Missouri. It's located in the Southeast Missouri region of the state.