Land for sale in Orangeburg County, South Carolina, recently totaled almost $132 million and approximately 6,000 acres. Orangeburg County ranks 14th out of 46 counties in South Carolina for the combined amount of land currently advertised for sale. Among cities in Orangeburg County with farms, hunting land and other rural land and acreage for sale, Orangeburg had the most land for sale. Orangeburg County is one of the ten biggest counties in South Carolina (1,127 square miles). It's located in the Low Country South Carolina region of South Carolina.