There was a total of almost $60 million of land and rural real estate for sale in Missouri's Oregon County recently on Land.com. The total acreage of all Oregon County ranches, farms, hunting land and other rural land and acreage for sale was 9,000 acres. Oregon County ranks 44th out of 115 counties in the Show Me State for the total acreage of land currently advertised for sale. Of all locations in Oregon County with land for sale, Alton had the most land for sale. Oregon County is Missouri's 14th largest county (791 square miles). It's located in the Southeast Missouri region of Missouri.