Land for sale in Pamlico County recently totaled almost $106 million and almost 7,000 acres. Pamlico County ranks 45th out of 100 counties in the Tar Heel State for the total acreage of land currently advertised for sale. Oriental featured the most land for sale. Based on its natural assets, Pamlico County's economy is dependent on tourism and recreation. Pamlico County is the 33rd biggest county (561 square miles) in North Carolina. It's located in the Coast North Carolina region of North Carolina.