Land for sale in Preble County, Ohio, recently totaled nearly $15 million and almost 1,000 acres. Preble County ranks 62nd out of 88 counties in the state for the total acreage of land currently advertised for sale. Of all locations in Preble County with farms, ranches, and rural real estate for sale, Eaton had the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Preble County. Preble County is Ohio's 53rd largest county (426 square miles). It's located in the Southwest Ohio region of Ohio.