Land for sale in Rio Blanco County, Colorado, recently totaled around $75 million and around 100,000 acres. Rio Blanco County ranks 43rd in the Centennial State for the total acreage of land currently advertised for sale. Among cities in Rio Blanco County with land for sale, Meeker had the most land for sale. Mining and mineral extraction-related services are the main economic drivers in this part of Colorado. Rio Blanco County is one of the ten largest counties in Colorado (3,222 square miles). It's located in the Northwest Colorado region of the state.