The combined value of farms and ranches for sale in Saint Francois County recently on Land.com was $49 million. This represents almost 3,000 acres of land for sale in Saint Francois County. Saint Francois County ranks 35th in the Gateway State for the total number of acres of land currently advertised for sale. Of all locations in Saint Francois County with land for sale, Bonne Terre had the most land for sale. Saint Francois County is the 96th biggest county (454 square miles) in Missouri. It's located in the Southeast Missouri region of the state.