The overall value of farms and ranches for sale in Missouri's Saint Francois County recently on Land.com was almost $39 million. This represents nearly 3,000 acres of farms, ranches, and rural real estate for sale in Saint Francois County. Saint Francois County ranks 43rd in the Gateway State for the combined amount of land currently advertised for sale. Bonne Terre had the most land for sale. Saint Francois County is Missouri's 96th biggest county (454 square miles). It's located in the Southeast Missouri region of the state.