The total value of farms, ranches, and rural real estate for sale in Wapello County recently on Land.com was approximately $16 million. This represents 1,000 acres of land for sale in Wapello County. Wapello County ranks 31st out of 99 counties in the Hawkeye State for the combined amount of land currently advertised for sale. Ottumwa featured the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Wapello County. Wapello County is Iowa's 84th biggest county (436 square miles). It's located in the Central Iowa region of the state.