The value of all land for sale in Wythe County recently was nearly $71 million, representing a combined 2,096 acres of land for sale in Wythe County. Wythe County ranks 39th in the state for the combined amount of land currently advertised for sale. Of all farms, hunting land and other rural land and acreage for sale in Wythe County, Wytheville featured the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Wythe County. Wythe County is Virginia's 37th largest county (464 square miles). It's located in the Mountain Virginia region of Virginia.