Land for sale in Wythe County recently totaled $65 million and almost 3,000 acres. Wythe County ranks 28th out of 133 counties in the Old Dominion for the total number of acres of land currently advertised for sale. Of all farms and rural real estate for sale in Wythe County, Wytheville had the most land for sale. Manufacturing and related services are the largest economic sectors in Wythe County. Wythe County is the 37th biggest county (464 square miles) in Virginia. It's located in the Mountain Virginia region of Virginia.