Property
$2,900,000400 Acres5 beds • 2 baths • 2,496 sq ft
For Sale
For Sale
$2,900,000400 Acres
For Sale
5 beds • 2 baths • 2,496 sq ft

2575 County Road 422, Thomasville, MO 65438 - Oregon County

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Property ID 25332959

Southern MO. Ranch

Southern Missouri Ranch 400 Acres with Middlefork River, Two Homes & Multiple Improvements

Thomasville, Missouri Oregon County

Discover the perfect blend of privacy, productivity, and natural beauty on this impressive 400-acre Missouri Ozarks Ranch in Oregon County. With wide-open pasture, rolling timber, live water, and two homes already in place, this property is ready for livestock, homesteading, recreation, or a peaceful rural lifestyle.

A major highlight of this property is the Middlefork River, a clear, year-round live water source that meanders through the land. Combined with five ponds, including a large spring-fed pond, this ranch offers exceptional water resources for livestock and wildlife.

Property Highlights

400 acres 200 acres open pasture/hay ground, balance in mature timber

Middlefork River flowing year-round through the property

Five ponds, including a spring-fed pond

Fenced and cross-fenced for livestock

Barn and equipment shed for storage and operations

Three wells total, including one serving the second home area

Excellent hunting & fishing with abundant wildlife

The main home features 5 bedrooms, 2 bathrooms, an unfinished basement, an updated kitchen, and even a secondary kitchen for canningperfect for those looking to live sustainably. Covered front and back decks overlook the surrounding pastures and timber.

Adding tremendous value, this property also includes a second home, making it ideal for multi-generational living, rental income, or space for ranch hands. A barn, additional well, and multiple outbuildings provide excellent utility for equipment storage, livestock operations, and homesteading needs.

Located in Thomasville, youre just minutes from some of the most iconic waterways in the Missouri Ozarks, including the Eleven Point River, Jacks Fork River, and Current River, and a short drive to West Plains for healthcare, shopping, dining, and the university campus.

Key Features

Two homes on the property ideal for multi-generational living or rental use

Updated kitchen in the main home plus a second canning kitchen

Barn, outbuildings, and additional well near second home

Livestock-ready setup with extensive fencing and water resources

Prime hunting with deer, turkey, and small game

River and pond fishing opportunities

Private & secluded setting, yet convenient to West Plains

Perfect for livestock, homesteading, recreation, or a private Ozarks retreat

This remarkable Oregon County ranch offers a rare opportunity to own a truly versatile property with live water, multiple homes, and endless possibilities

Directions

Highway 160 towards Thomasville - Left on County Road 419 - Left on County Road 422 - Property on Right

Resources

Links
Property Website
Contact Seller
United Country Missouri Ozarks Realty, Inc

West Plains, MO

(573) 728-2768
Listing provided by
Kim Grennan
United Country Missouri Ozarks Realty, Inc(573) 728-2768
Source: MLS# 60307343
Listing last updated: November 22, 2025 at 12:23 PM
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Kim Grennan

United Country Missouri Ozarks Realty, Inc

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Kim Grennan

Kim Grennan

United Country Missouri Ozarks Realty, Inc