Land for sale in Calhoun County, South Carolina, recently totaled around $29 million and almost 2,000 acres. Calhoun County ranks 44th in the Palmetto State for the total acreage of land currently advertised for sale. There were three properties listed as sold in Calhoun County through the Land Network Comparable Sales Program. This represented a total value of $633,200. Saint Matthews had the most land for sale. Manufacturing and related services are the largest economic sectors in Calhoun County. Calhoun County is the 46th largest county (392 square miles) in South Carolina. It's located in the Low Country South Carolina region of the state.