There was a combined almost $17 million of farms, hunting land and other rural land and acreage for sale in Calhoun County, South Carolina, recently on Land.com. The total size of all Calhoun County farms and rural real estate for sale was around 1,000 acres. Calhoun County ranks 43rd in South Carolina for the total number of acres of land currently advertised for sale. Saint Matthews featured the most land for sale. Manufacturing and related services are the largest economic sectors in Calhoun County. Calhoun County is South Carolina's 46th largest county (392 square miles). It's located in the Low Country South Carolina region of South Carolina.