The value of all farms, rural land, hunting land and other land for sale in Cherokee County recently was approximately $107 million, representing a combined 3,404 acres of land for sale in Cherokee County. Cherokee County ranks 22nd in South Carolina for the combined amount of land currently advertised for sale. Of all farms, rural land, hunting land and other land for sale in Cherokee County, Gaffney featured the most land for sale. Manufacturing and related services are the largest economic sectors in Cherokee County. Cherokee County is South Carolina's 43rd largest county (397 square miles). It's located in the Upstate South Carolina region of the state.