There was a combined almost $118 million of land for sale in South Carolina's Cherokee County recently on Land.com. The total size of all Cherokee County farms and rural land for sale was around 3,000 acres. Cherokee County ranks 22nd in South Carolina for the total acreage of land currently advertised for sale. There were two properties listed as sold in Cherokee County through the Land Network Comparable Sales Program. This represented a total value of $405,000. Gaffney had the most land for sale. Manufacturing and related services are the largest economic sectors in Cherokee County. Cherokee County is the 43rd biggest county (397 square miles) in South Carolina. It's located in the Upstate South Carolina region of South Carolina.