Of 46 counties in the Palmetto State, Cherokee County ranks 43rd by size (397 square miles). Cherokee County is in Upstate South Carolina. Cherokee County, South Carolina, includes roughly 1,000 acres of riverfront land for sale based on recent Land Network data. The combined market value of farms and rural land for sale here was almost $3 million. Browse all waterfront property for sale in Cherokee County on the Land Network to find the marina, lakefront and other recreational property that meets your needs, from waterside land perfect as a retirement investment to existing residential waterfront land and property for hunting, fishing and other outdoor-recreation pursuits! The most common type of land for sale by combined acreage in Cherokee County is residential property.