Of 99 counties in the Cyclone State, Clayton County is fifth in terms of its size (792 square miles). Clayton County is in Eastern Iowa. Recent Land Network data shows almost 1,000 acres of ranches for sale in Iowa's Clayton County, which is valued at a combined $867,000. Browse all Clayton County ranches for sale on the Land Network to find the ranch that's right for your business or commercial needs, from the sprawling legacy ranch to unbelievable residential ranch for your second home, investment property or retirement nest egg. The most common type of land for sale by combined acreage in Clayton County is residential property.