A total of almost 6,000 acres were listed for sale in Colleton County recently, representing a total value of almost $169 million in Colleton County land for sale. Colleton County ranks 21st out of 46 counties in South Carolina for the total number of acres of land currently advertised for sale. Walterboro had the most land for sale. Colleton County is one of the ten biggest counties in South Carolina (1,133 square miles). It's located in the Low Country South Carolina region of the state.