A combined almost 1,000 acres were listed for sale in Hughes County, South Dakota, recently; the combined value of all Hughes County farms and ranches for sale was almost $7 million. Hughes County ranks 31st out of 66 counties in the Coyote State for the total acreage of land currently advertised for sale. Among cities in Hughes County with land and rural real estate for sale, Pierre had the most land for sale. Government and state-level services are the main economic drivers in Hughes County. Hughes County is South Dakota's 42nd biggest county (800 square miles). It's located in the Great Lakes South Dakota region of South Dakota.