There was a combined nearly $6 million of farms and ranches for sale in Hughes County, South Dakota, recently on Land.com. The total of all Hughes County farms and ranches for sale was almost 1,000 acres. Hughes County ranks 33rd in the Coyote State for the total acreage of land currently advertised for sale. Of all locations in Hughes County with farms, ranches, hunting land and other land for sale, Pierre had the most land for sale. Government and state-level services are the main economic drivers in Hughes County. Hughes County is South Dakota's 42nd largest county (800 square miles). It's located in the Great Lakes South Dakota region of the state.