Land for sale in Mississippi's Issaquena County recently totaled nearly $9 million and approximately 4,000 acres. Issaquena County ranks 82nd out of 82 counties in the Magnolia State for the combined amount of land currently advertised for sale. Rolling Fork featured the most land for sale. Agriculture and farming drives the Issaquena County economy, with 97 farms recorded in the county during the U.S. Census in 2012. Farming activities in Issaquena County generate annual revenues of $1 million, 0 percent of which comes from crops and 0 percent from livestock bred in the county. Issaquena County is the 65th biggest county (441 square miles) in Mississippi. It's located in the Delta Mississippi region of the state.