Of 82 counties in the state, Issaquena County ranks 65th in terms of size (441 square miles). Issaquena County is in Delta Mississippi. Mississippi's Issaquena County has almost 1,000 acres of residential land for sale based on recent Land Network data. The combined market value of farms and rural land for sale here was almost $800,000. Browse all residential property and land for sale in Issaquena County to find residential land and properties that suit your lifestyle needs, from existing residential homes and estates to land ready for future residential-property development. The most common type of land for sale by combined acreage in Issaquena County is recreational property.