South Texas is typically classified as the area between the San Antonio metro area and south to the Rio Grande and Gulf of Mexico. There was a combined almost $29 million of land and rural real estate for sale in Texas's Karnes County recently on Land.com. The total size of all Karnes County ranches, farms, hunting land and other rural land and acreage for sale was almost 3,000 acres. Karnes County ranks 188th in the Lone Star State for the combined amount of land currently advertised for sale. Of all land for sale in Karnes County, Kenedy featured the most land for sale. Government and state-level services are the main economic drivers in Karnes County. Karnes County is Texas's 212th biggest county (753 square miles). It's located in the San Antonio Texas region of Texas.