Land for sale in Mississippi's Lee County recently totaled almost $111 million and approximately 2,000 acres. Lee County ranks 10th in the Magnolia State for the total number of acres of land currently advertised for sale. Of all locations in Lee County with land for sale, Tupelo featured the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Lee County. Lee County is the 61st largest county (453 square miles) in Mississippi. It's located in the Hills Mississippi region of the state.