Land for sale in Lee County, Mississippi, recently totaled around $139 million and around 3,000 acres. Lee County ranks eighth in the Hospitality State for the combined amount of land currently advertised for sale. Of all land for sale in Lee County, Tupelo had the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Lee County. Lee County is the 61st biggest county (453 square miles) in Mississippi. It's located in the Hills Mississippi region of the state.