The value of land for sale in Mississippi County, Missouri, recently on Land.com was almost $19 million. This represents almost 2,000 acres of farms, ranches, hunting land and other land for sale in Mississippi County. Mississippi County ranks 96th out of 115 counties in the Ozark State for the combined amount of land currently advertised for sale. Of all locations in Mississippi County with ranches, farms, hunting land and other rural land and acreage for sale, Charleston had the most land for sale. Mississippi County is Missouri's 103rd largest county (428 square miles). It's located in the Southeast Missouri region of Missouri.