A total of almost 2,000 acres were listed for sale in Mississippi County, Missouri, recently; the combined value of all Mississippi County farms, ranches, hunting land and other land for sale was around $17 million. Mississippi County ranks 94th in the state for the total acreage of land currently advertised for sale. Charleston featured the most land for sale. Mississippi County is the 103rd largest county (428 square miles) in Missouri. It's located in the Southeast Missouri region of Missouri.