The value of all farms, rural land, hunting land and other land for sale in South Carolina's Pickens County recently was $406 million, representing a total of 3,560 acres of land for sale in Pickens County. Pickens County ranks ninth in the Palmetto State for the total acreage of land currently advertised for sale. Among cities in Pickens County with farms and rural real estate for sale, Pickens had the most land for sale. From an economic perspective, government and state-level services contribute most to Pickens County's overall GDP. Pickens County is the 33rd biggest county (512 square miles) in South Carolina. It's located in the Upstate South Carolina region of South Carolina.