Of 46 counties in the state, Pickens County ranks 33rd in terms of size (512 square miles). Pickens County is in Upstate South Carolina. A recent survey of Land Network data includes almost 1,000 acres of ranches for sale in South Carolina's Pickens County, which is valued at a combined $159,950. Browse all Pickens County ranches for sale on the Land Network to find the ranch that's right for your business or commercial needs, from the sprawling legacy ranch to unbelievable residential ranch for your second home, investment property or retirement nest egg. The most common type of land for sale by combined acreage in Pickens County is residential property.