Land for sale in Prentiss County, Mississippi, recently totaled around $22 million and around 5,000 acres. Prentiss County ranks 25th out of 82 counties in the Magnolia State for the combined amount of land currently advertised for sale. Booneville had the most land for sale. From an economic perspective, manufacturing and related services are the main sectors in Prentiss County. Prentiss County is Mississippi's 71st largest county (418 square miles). It's located in the Hills Mississippi region of the state.